Tgf-β/smad3 signaling regulates brown adipocyte induction in white adipose tissue
In conditions of energy excess, the white adipose tissue accumulates fat in the form of triglycerides, whilst brown adipose tissue has the potential stimulate energy expenditure by dissipation of fat to produce heat and maintain body temperature. Thus, chronic treatment with rosiglitazone promotes the expression of brown fat genes, mitochondriogenesis, and thermogenesis capacity [>]